Se hela listan på frontiersin.org
Increased opioidergic tone may have a role. Biliary or obstructive liver disease especially primary biliary cirrhosis; Chronic renal failure especially in dialysis patients; Haematological disease especially iron deficiency, polycythaemia rubra vera, lymphoma and myeloma; Advanced malignancy; Thyroid disease (hypo- or hyper-)
Opioids are one of the most prescribed drug classes for treating acute pain. However, chronic use is often associated with tolerance as well as debilitating side effects, including nausea and depen In particular, the hypothesis that increased central opioidergic tone is involved is supported by three observations: opiate agonists induce opioid receptor-mediated scratching activity of central origin, central opioidergic tone is increased in cholestasis and opiate antagonists reduce scratching activity in cholestatic patients. However, luteinizing hormone (LH) pulse frequency and pulse amplitude were not affected by naloxone treatment. Further, chronic naloxone treatment of zebu heifers did not induce puberty;In a follow-up study, the effects of dietary restriction and endogenous opioidergic tone on the regulation of progesterone, cortisol and LH were investigated. Analogous to the pruritus that results from the pharmacological increase in opioidergic tone by central morphine ( 4,5 ), it is hypothesized that increased opioidergic tone in cholestasis may mediate the pruritus, at least in part, by a central mechanism ( 6 ). The effects of JDTic on relapse-like ethanol intake in Long-Evans rats was examined because of the positive results from the previous study, earlier reports suggesting an increased tone of the accumbal κ-opioidergic system as ethanol addiction evolves and the lack of knowledge on what role the nucleus accumbens shell κ-opioid receptors have in relapse to ethanol intake. Opioidergic tone and pain susceptibility: interactions between reward systems and opioid receptors.
Pruritus is a symptom of cholestasis, which appears to result, in part, from increased opioidergic tone; a central mechanism has been proposed. We then examined whether OFQ would produce hyperalgesia in the absence of such an endogenous opioidergic tone.Neither naloxone (1 mg kg−1; s.c.) nor OFQ (up to 30 nmol; i.c.v.) alone induced any significant change in mean hot plate latency. Increased opioidergic tone may have a role. Biliary or obstructive liver disease especially primary biliary cirrhosis; Chronic renal failure especially in dialysis patients; Haematological disease especially iron deficiency, polycythaemia rubra vera, lymphoma and myeloma; … 2020-09-23 2021-03-09 1995-05-01 Summary: The role of opioidergic system in controlling gonadotropin secretion in elderly men still remains uncertain.
An opioidergic agent (or drug) is a chemical which functions to directly modulate the opioid neuropeptide systems (i.e., endorphin, enkephalin, dynorphin, nociceptin) in the body or brain. Examples include opioid analgesics such as morphine and opioid antagonists such as naloxone.
However, initiation of therapy with an opiate antagonist in a cholestatic patient may precipitate a transient opioid withdrawal– like reaction. A … increase in opioidergic tone (and thus no danger of a withdrawal syndrome if an opioid antagonist is given). Instead, the ratio between m-opioid (pruritus-inducible) and k-opioid (pruritus-suppressive) re-ceptors alters in favor of the former.69,70 This predisposes to the onset or exacerbation of pruritus. It 2.
Increased opioidergic tone may have a role. Biliary or obstructive liver disease especially primary biliary cirrhosis; Chronic renal failure especially in dialysis patients; Haematological disease especially iron deficiency, polycythaemia rubra vera, lymphoma and myeloma; Advanced malignancy; Thyroid disease (hypo- or hyper-)
Positive corrective modulation of sex hormones, HPTA functionality, and glucocorticoidergic tone. The withdrawal response is due to the elevated opioidergic tone found in this condition. These withdrawal reactions can be minimized, or avoided completely, by infusing low doses of naloxone before giving small oral doses of an orally bioavailable opiate antagonist. Pruritus: ↑ opioidergic tone • Several lines of evidence support a role for an ↑ opioidergic tone in the pathogenesis of pruritus in PBC. • First, as opposed to healthy volunteers, pts with PBC develop withdrawal- like symptoms after taking an opioid antagonist.
A high innate µ-opioidergic tone in the nucleus accumbens shell of alcohol-preferring Alko Alcohol (AA) rats has been proposed to account for
The effects of JDTic on relapse-like ethanol intake in Long-Evans rats was examined because of the positive results from the previous study, earlier reports suggesting an increased tone of the accumbal κ-opioidergic system as ethanol addiction evolves and the lack of knowledge on what role the nucleus accumbens shell κ-opioid receptors have in relapse to ethanol intake.
Pension forsakring
However, chronic use is often associated with tolerance as well as debilitating side effects, including nausea and depen The pruritus of cholestasis may at least in part have its origins in the central nervous system. 110 The authors suggest several mechanisms whereby this might be the case: opioid agonists induce pruritus by a central mechanism, central opioidergic tone is increased in cholestasis and opioid antagonists can improve the symptom. 2019-08-01 · Additionally, external stressors at parturition may induce an increase in central nervous system opioidergic tone, which in turn may inhibit oxytocin release. Studies on stress and the progress of parturition so far have largely focussed on polytocous species such as the rat, mouse and pig. 2012-08-01 · Also, the raised incidence of silent myocardial ischemia in athletes may be explained by raised opioidergic tone, thereby blunting the alerting pain symptoms of ischemia.
This approach was based on evidence that patients with AD show increased CSF levels of opioid peptides and a reduction in opioid binding receptors in the dentate gyrus. 20,29,33 In this study, the opioid receptor antagonist, naloxone, induced an increase in sensitivity to thermal stimulation suggesting that increased opioidergic tone in the transgenic mice is responsible for the altered thermal thresholds.
Källkritisk granskning av artikel
klarna pris
skillnaden mellan svenska och svenska som andraspråk
hyra per kvadratmeter
beräkna vinstskatt lägenhet
Findings consistent with the hypothesis that increased central opioidergic tone contributes to the pruritus of cholestasis provide a rationale for treating this form of pruritus with opiate antagonists. However, initiation of therapy with an opiate antagonist in a cholestatic patient may precipitate a transient opioid withdrawal-like reaction.
Substances of abuse dysregulate key brain systems involved in motivation, reward, decision-making and memory. As drug use evolves into a compulsive addiction, there are adaptations in these systems, mediated by a number of different neurotransmitters. The mesolimbic dopaminergic pathway plays a central role in the pleasurable and positive reinforcing effects of drugs. Opioids are one of the most prescribed drug classes for treating acute pain.